2. Academic Validation
  3. Structure activity studies of a novel cytotoxic benzodiazepine

Structure activity studies of a novel cytotoxic benzodiazepine

  • Bioorg Med Chem Lett. 2003 Oct 6;13(19):3327-30. doi: 10.1016/s0960-894x(03)00683-8.
Anthony Boitano 1,  Cory D Emal,  Francesco Leonetti,  Neal B Blatt,  Thomas A Dineen,  Jonathan A Ellman,  William R Roush,  Anthony W Opipari,  Gary D Glick
Affiliations

Affiliation

  • 1 Department of Chemistry, University of Michigan, 930 North University Avenue, Ann Arbor, MI 48109-1055, USA.
PMID: 12951119 DOI: 10.1016/s0960-894x(03)00683-8
Abstract

Analogues of Bz-423, a pro-apoptotic 1,4-benzodiazepine with potent activity in animal models of systemic lupus erythematosus and rheumatoid arthritis, have been designed, synthesized, and evaluated in cell-culture assays. The results of these experiments have defined the structural elements of this new cytotoxic agent required for activity.

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