2. Academic Validation
  3. Synergistic effect of flavones and flavonols against herpes simplex virus type 1 in cell culture. Comparison with the antiviral activity of propolis

Synergistic effect of flavones and flavonols against herpes simplex virus type 1 in cell culture. Comparison with the antiviral activity of propolis

  • J Nat Prod. 1992 Dec;55(12):1732-40. doi: 10.1021/np50090a003.
M Amoros 1,  C M Simões,  L Girre,  F Sauvager,  M Cormier
Affiliations

Affiliation

  • 1 Laboratoire de Pharmacognosie et Mycologie, Faculté de Pharmacie, Université de Rennes I, France.
PMID: 1338212 DOI: 10.1021/np50090a003
Abstract

The in vitro activity against herpes simplex virus type 1 of the major Flavonoids identified in propolis was investigated. Flavonols were found to be more active than Flavones, the order of importance being galangin, kaempferol, and quercetin. The efficacy against HSV-1 of binary flavone-flavonol combinations has been also investigated. The synergy demonstrated by all combinations could explain why propolis is more active than its individual compounds.

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