2. Academic Validation
  3. Synthesis and antiviral evaluation of 3-hydroxy-2-methylpyridin-4-one dideoxynucleoside derivatives

Synthesis and antiviral evaluation of 3-hydroxy-2-methylpyridin-4-one dideoxynucleoside derivatives

  • Bioorg Med Chem Lett. 2003 Dec 15;13(24):4371-4. doi: 10.1016/j.bmcl.2003.09.033.
Karine Barral 1,  Robert C Hider,  Jan Balzarini,  Johan Neyts,  Erik De Clercq,  Michel Camplo
Affiliations

Affiliation

  • 1 Laboratoire des Matériaux Moléculaires et des Biomatériaux (UMR-CNRS 6114), Faculté des Sciences de Luminy, case 901, 13288 09, Marseille cedex, France.
PMID: 14643328 DOI: 10.1016/j.bmcl.2003.09.033
Abstract

We describe the synthesis and the Antiviral evaluation of novel alpha and beta dideoxynucleoside derivatives in which the base has been replaced by a 3-hydroxy-2-methylpyridin-4-one. The syntheses were successfully achieved by the use of the standard Vorbrüggen coupling conditions. Moderate activity of these compounds were found on herpes simplex virus (HSV) type 1 and type 2.

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