2. Academic Validation
  3. Excisanin H, a novel cytotoxic 14,20-epoxy-ent-kaurene diterpenoid, and three new ent-kaurene diterpenoids from Rabdosia excisa

Excisanin H, a novel cytotoxic 14,20-epoxy-ent-kaurene diterpenoid, and three new ent-kaurene diterpenoids from Rabdosia excisa

  • J Nat Prod. 2004 Mar;67(3):373-6. doi: 10.1021/np030357r.
Ming-Yu Gui 1,  Yutaka Aoyagi,  Yong-Ri Jin,  Xu-Wen Li,  Tomoyo Hasuda,  Koichi Takeya
Affiliations

Affiliation

  • 1 School of Pharmacy, Tokyo University of Pharmacy and Life Science, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan.
PMID: 15043413 DOI: 10.1021/np030357r
Abstract

A novel 14,20-epoxy-ent-kaurene diterpenoid, excisanin H (1), and three new ent-kaurene Diterpenoids, 2-4, were isolated from aerial parts of Rabdosia excisa along with eight known ent-kaurene Diterpenoids, 5-12. The structural elucidations were made using spectral (HREIMS, IR, (1)H, (13)C, and 2D NMR) methods. The absolute configuration of 1 was determined by demonstrating that oxidation of kamebakaurin (8) produced excisanin H (1). These ent-kaurene Diterpenoids all showed significant cytotoxic activity against P388 murine leukemia cells.

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