2. Academic Validation
  3. Cyclooxygenase inhibitory flavonoids from the stem bark of Semecarpus anacardium Linn

Cyclooxygenase inhibitory flavonoids from the stem bark of Semecarpus anacardium Linn

  • Phytother Res. 2004 Jul;18(7):582-4. doi: 10.1002/ptr.1492.
C Selvam 1,  Sanjay M Jachak,  K K Bhutani
Affiliations

Affiliation

  • 1 Department of Natural Products, National Institute of Pharmaceutical Education and Research, Punjab, India.
PMID: 15305321 DOI: 10.1002/ptr.1492
Abstract

The ethyl acetate extract of stem bark of Semecarpus anacardium showing in vivo anti-in fl ammatory activity in carrageenan induced rat paw edema assay was investigated in order to identify its active compounds. Chemical investigation of the ethyl acetate extract of S.anacardium afforded 3,4,2',4'-tetrahydroxychalcone (butein) and 7,3',4'-trihydroxy fl avone. Evaluation of COX-1 inhibitory activity of 3,4,2',4'-tetrahydroxychalcone and 7,3',4'-trihydroxy fl avone provided the IC(50) values of 28.4 and 36.7 micro M respectively. Further investigation of these compounds for COX-2 inhibitory activity revealed moderate potency towards this enzyme.

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