2. Academic Validation
  3. Total synthesis and antiangiogenic activity of cyclopentane analogues of fumagillol

Total synthesis and antiangiogenic activity of cyclopentane analogues of fumagillol

  • Bioorg Med Chem Lett. 2005 Aug 1;15(15):3580-3. doi: 10.1016/j.bmcl.2005.05.065.
Byeong-Seon Jeong 1,  Nam Song Choi,  Soon Kil Ahn,  Hoon Bae,  Hak Sung Kim,  Deukjoon Kim
Affiliations

Affiliation

  • 1 New Drug Research Laboratories, Chong Kun Dang Research Institute, Cheonan 330-831, Republic of Korea.
PMID: 15978809 DOI: 10.1016/j.bmcl.2005.05.065
Abstract

Novel cyclopentane analogues of fumagillol were synthesized and their endothelial cell proliferation inhibitory activities were evaluated. The cyclopentane-fumagillol derivatives were synthesized from (-)-2,3-O-isopropylidene-D-erythronolactone via stereoselective glycolate Claisen rearrangement and intramolecular ester enolate alkylation as key steps.

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