2. Academic Validation
  3. Estrogen receptor beta selective ligands: discovery and SAR of novel heterocyclic ligands

Estrogen receptor beta selective ligands: discovery and SAR of novel heterocyclic ligands

  • Bioorg Med Chem Lett. 2005 Dec 15;15(24):5562-6. doi: 10.1016/j.bmcl.2005.08.010.
Richard Chesworth 1,  Matthew D Wessel,  Lisa Heyden,  F Michael Mangano,  Michael Zawistoski,  Laura Gegnas,  David Galluzzo,  Bruce Lefker,  Kimberly O Cameron,  Jeanne Tickner,  Bihong Lu,  Tessa A Castleberry,  Donna N Petersen,  Amy Brault,  Pia Perry,  Oicheng Ng,  Thomas A Owen,  Lydia Pan,  Hua-Zhu Ke,  Thomas A Brown,  David D Thompson,  Paul DaSilva-Jardine
Affiliations

Affiliation

  • 1 Cardiovascular and Metabolic Diseases, Medicinal Chemistry, Pfizer Global Research and Development, Groton Laboratories, Eastern Point Road, Groton, CT 06340, USA. rchesworth@gmail.com
PMID: 16219463 DOI: 10.1016/j.bmcl.2005.08.010
Abstract

A series of ligands with varying heterocyclic cores and substituents that display a range of selectivity's (up to >100x) for ER-beta over ER-alpha are reported.

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