2. Academic Validation
  3. Synthesis and antiviral activity of 7-deazaneplanocin A against orthopoxviruses (vaccinia and cowpox virus)

Synthesis and antiviral activity of 7-deazaneplanocin A against orthopoxviruses (vaccinia and cowpox virus)

  • Bioorg Med Chem Lett. 2006 Jan 15;16(2):285-7. doi: 10.1016/j.bmcl.2005.10.007.
Balakumar Arumugham 1,  Hyo-Joong Kim,  Mark N Prichard,  Earl R Kern,  Chung K Chu
Affiliations

Affiliation

  • 1 University of Georgia College of Pharmacy, Athens, GA 30602, USA.
PMID: 16275078 DOI: 10.1016/j.bmcl.2005.10.007
Abstract

An efficient method for the synthesis of 7-deazaneplanocin A (2) has been accomplished by the condensation of cyclopentenol 3 with 6-chloro-7-deazapurine followed by subsequent functional group manipulations. The synthesized 7-deazaneplanocin A (2) exhibited potent Antiviral activity against cowpox and vaccinia viruses without cytotoxicity in HFF cells.

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