2. Academic Validation
  3. Androstenediol analogs as ER-beta-selective SERMs

Androstenediol analogs as ER-beta-selective SERMs

  • Bioorg Med Chem Lett. 2006 Feb 15;16(4):834-8. doi: 10.1016/j.bmcl.2005.11.014.
Timothy A Blizzard 1,  Candido Gude,  Jerry D Morgan 2nd,  Wanda Chan,  Elizabeth T Birzin,  Marina Mojena,  Consuelo Tudela,  Fang Chen,  Kristin Knecht,  Qin Su,  Bryan Kraker,  Ralph T Mosley,  Mark A Holmes,  Nandini Sharma,  Paula M D Fitzgerald,  Susan P Rohrer,  Milton L Hammond
Affiliations

Affiliation

  • 1 Merck Research Laboratories, PO Box 2000, Rahway NJ 07065, USA. tim_blizzard@merck.com
PMID: 16309907 DOI: 10.1016/j.bmcl.2005.11.014
Abstract

A series of 19-substituted androstenediol derivatives was prepared. Some of the novel analogs were surprisingly potent and selective ligands for ER-beta.

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