2. Academic Validation
  3. Semisynthesis of C-ring modified triptolide analogues and their cytotoxic activities

Semisynthesis of C-ring modified triptolide analogues and their cytotoxic activities

  • Bioorg Med Chem Lett. 2006 Apr 1;16(7):1947-9. doi: 10.1016/j.bmcl.2005.12.098.
Yutaka Aoyagi 1,  Yukio Hitotsuyanagi,  Tomoyo Hasuda,  Haruhiko Fukaya,  Koichi Takeya,  Ritsuo Aiyama,  Takeshi Matsuzaki,  Shusuke Hashimoto
Affiliations

Affiliation

  • 1 School of Pharmacy, Tokyo University of Pharmacy & Life Science, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan.
PMID: 16455242 DOI: 10.1016/j.bmcl.2005.12.098
Abstract

Several C-ring modified analogues of a potent antileukemic diterpene, triptolide (1), were synthesized and their structure-activity relationships were studied.

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