2. Academic Validation
  3. Synthesis and evaluation of N-aryl pyrrolidinones as novel anti-HIV-1 agents. Part 1

Synthesis and evaluation of N-aryl pyrrolidinones as novel anti-HIV-1 agents. Part 1

  • Bioorg Med Chem Lett. 2006 Jul 1;16(13):3430-3. doi: 10.1016/j.bmcl.2006.04.012.
Baogen Wu 1,  Kelli Kuhen,  Truc Ngoc Nguyen,  David Ellis,  Beth Anaclerio,  Xiaohui He,  Kunyong Yang,  Donald Karanewsky,  Hong Yin,  Karen Wolff,  Kimberly Bieza,  Jeremy Caldwell,  Yun He
Affiliations

Affiliation

  • 1 Genomics Institute of the Novartis Research Foundation, GNF, 10675 John Jay Hopkins Dr. San Diego, CA 92121, USA. bwu@gnf.org
PMID: 16632349 DOI: 10.1016/j.bmcl.2006.04.012
Abstract

The synthesis and preliminary structure-activity relationship of a series of pyrrolidinones are described. These pyrrolidinones have been characterized as novel non-nucleoside Reverse Transcriptase inhibitors (NNRTIs) which are highly potent against wild-type and drug-resistant human immunodeficiency viruses (HIV-1).

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