2. Academic Validation
  3. Discovery of a novel series of inhibitors of human cytomegalovirus primase

Discovery of a novel series of inhibitors of human cytomegalovirus primase

  • Bioorg Med Chem Lett. 2006 Sep 15;16(18):4879-83. doi: 10.1016/j.bmcl.2006.06.066.
T D Cushing 1,  J Adrian,  X Chen,  H DiMaio,  B Doughan,  J Flygare,  L Liang,  V Mayorga,  S Miao,  H Mellon,  M G Peterson,  J P Powers,  F Spector,  C Stein,  M Wright,  D Xu,  Q Ye,  J Jaen
Affiliations

Affiliation

  • 1 Amgen Inc., 1120 Veterans Boulevard, South San Francisco, CA 94080, USA. tcushing@amgen.com
PMID: 16814545 DOI: 10.1016/j.bmcl.2006.06.066
Abstract

Infection by human cytomegalovirus (hCMV) remains a potent threat to susceptible people throughout the world. We have discovered a series of imidazolyl-pyrimidine compounds, which were found to be irreversible inhibitors of the hCMV UL70 primase based on results from radiolabeling and SAR studies. Two promising analogs are described that rival ganciclovir and cidofovir in Antiviral potency and possess improved cytotoxicity profiles.

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