2. Academic Validation
  3. Hydroxylated gedunin derivatives from Cedrela sinensis

Hydroxylated gedunin derivatives from Cedrela sinensis

  • J Nat Prod. 2006 Sep;69(9):1310-4. doi: 10.1021/np068021f.
Kumiko Mitsui 1,  Hiroaki Saito,  Ryota Yamamura,  Haruhiko Fukaya,  Yukio Hitotsuyanagi,  Koichi Takeya
Affiliations

Affiliation

  • 1 School of Pharmacy, Tokyo University of Pharmacy and Life Science, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan.
PMID: 16989525 DOI: 10.1021/np068021f
Abstract

Four new limonoids, 11alpha-hydroxygedunin (1), 11beta-hydroxygedunin (2), 7-deacetoxy-7alpha,11alpha-dihydroxygedunin (3), and 7-deacetoxy-7alpha,11beta-dihydroxygedunin (4), were isolated from the cortex of Cedrela sinensis, together with three known compounds, gedunin (5), 7-deacetoxy-7alpha-hydroxygedunin (6), and 11-oxogedunin (7). The structures of 1-4 were determined by a combination of 2D NMR experiments and chemical methods and by X-ray crystallography of 1 and 2.

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