2. Academic Validation
  3. Comparison of N,N'-diarylsquaramides and N,N'-diarylureas as antagonists of the CXCR2 chemokine receptor

Comparison of N,N'-diarylsquaramides and N,N'-diarylureas as antagonists of the CXCR2 chemokine receptor

  • Bioorg Med Chem Lett. 2007 Mar 15;17(6):1713-7. doi: 10.1016/j.bmcl.2006.12.067.
Brent W McCleland 1,  Roderick S Davis,  Michael R Palovich,  Katherine L Widdowson,  Michelle L Werner,  Miriam Burman,  James J Foley,  Dulcie B Schmidt,  Henry M Sarau,  Martin Rogers,  Kevin L Salyers,  Peter D Gorycki,  Theresa J Roethke,  Gary J Stelman,  Leonard M Azzarano,  Keith W Ward,  Jakob Busch-Petersen
Affiliations

Affiliation

  • 1 GlaxoSmithKline, 709 Swedeland Road, King of Prussia, PA 19406, USA.
PMID: 17236763 DOI: 10.1016/j.bmcl.2006.12.067
Abstract

N,N'-diarylsquaramides were prepared and evaluated as antagonists of CXCR2. The compounds were found to be potent and selective antagonists of CXCR2. Significant differences in SAR was observed relative to the previously described N,N'-diarylurea series. As was the case in the N,N'-diarylurea series, placing sulfonamide substituent adjacent to the acidic phenol significantly reduced the clearance in rat pharmacokinetic studies.

Figures
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z