2. Academic Validation
  3. beta-Sitosterol activates Fas signaling in human breast cancer cells

beta-Sitosterol activates Fas signaling in human breast cancer cells

  • Phytomedicine. 2007 Nov;14(11):747-54. doi: 10.1016/j.phymed.2007.01.003.
A B Awad 1,  M Chinnam,  C S Fink,  P G Bradford
Affiliations

Affiliation

  • 1 Department of Exercise and Nutrition Sciences, State University of New York at Buffalo, Buffalo, NY 14214, USA. awad@buffalo.edu
PMID: 17350814 DOI: 10.1016/j.phymed.2007.01.003
Abstract

beta-Sitosterol is the most abundant phytosterol. Phytosterols are enriched in legumes, oil seeds and unrefined plant oils as found in foods such as peanut butter, pistachios and sunflower seeds. beta-Sitosterol inhibits the growth of several specific types of tumor cells in vitro and decreases the size and the extent of tumor metastases in vivo. The effects of beta-sitosterol on the extrinsic apoptotic programmed cell death pathway in human breast MCF-7 and MDA-MB-231 adenocarcinoma cells were examined, along with the extent of its incorporation into cellular membranes and its effects on cell growth, expression of Fas receptor pathway proteins, and Caspase-8 activity. The results show that beta-sitosterol exposure promotes its enrichment in transformed cell membranes and significantly inhibits tumor cell growth. Concurrently, Fas levels and Caspase-8 activity are significantly increased. These actions are specific, as expression of Other proteins of the Fas receptor pathway, including Fas ligand, FADD, p-FADD and Caspase-8, remain unchanged. These findings support the hypothesis that beta-sitosterol is an effective apoptosis-promoting agent and that incorporation of more phytosterols in the diet may serve a preventive measure for breast Cancer.

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