Beta-Sitosterol (purity>80%) (Synonyms: 谷甾醇; β-Sitosterol (purity>80%); 22,23-Dihydrostigmasterol (purity>80%))

目录号: HY-N0171 纯度: ≥80.0%: FAQs
Data Sheet SDS COA 产品使用指南

摩尔计算器

Beta-Sitosterol (purity>80%) 主要包括 β-谷甾醇 (≥80%)、豆甾醇、菜油甾醇和菜籽甾醇。Beta-Sitosterol 是一种植物甾醇。Beta-Sitosterol (purity>80%) 会干扰多种细胞信号通路，包括细胞周期，细胞凋亡，增殖，存活，侵袭，血管生成和炎症等。

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Beta-Sitosterol (purity>80%) Chemical Structure

CAS No. : 83-46-5

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规格	价格	是否有货
100 mg	￥500	In-stock
1 g	￥700	In-stock
5 g	￥1000	In-stock
10 g		询价
50 g		询价

or 大包装询价

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Beta-Sitosterol (purity>98%) In-stock
Beta-Sitosterol (Standard) 询价

MCE 顾客使用本产品发表的 5 篇科研文献

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生物活性
实验参考方法
纯度 & 产品资料
参考文献

生物活性

Beta-Sitosterol (purity>80%) includes β-sitosterol (≥80%), stigmasterol, campesterol and brassicasterol mainly. Beta-Sitosterol is a plant sterol. Beta-Sitosterol (purity>80%) interfere with multiple cell signaling pathways, including cell cycle, apoptosis, proliferation, survival, invasion, angiogenesis, metastasis and inflammation^[1].

体外研究
(In Vitro)

生物活性引导的分离从大肠杆菌的己烷馏分中提供了三种化合物。籼稻，即 Beta-Sitosterol（β-sitosterol）、Stigmasterol 和 Lutein。发现这两种化合物都具有非常低的 PPL 抑制活性，即在 100 μg/mL（242 μM）时的抑制率为 2.99±0.80%（Beta-Sitosterol），在 100 μg/mL 时的抑制率分别为 2.68±0.38%（Stigmasterol） (243 μM)。对从Alpinia zerumbet 分离的 Beta-Sitosterol 和 Stigmasterol 的 PPL 弱抑制活性，IC₅₀ 值分别为 99.99±1.86 μg/mL 和 125.05±4.76 μg/mL。 Beta-Sitosterol 和 Stigmasterol 的 PPL 抑制活性较弱，在 100 μg/mL 时分别仅为 3.0±0.8% 和 2.7±0.4%（即 242 μM 和 243 μM），相比之下（在 100 μg/mL 时为 34.5±5.4% )，低于文献记载的值（即 100 μg/mL 时为 50% 的PPL 抑制率）。 Sitosterol 是从 Aloe vera 的叶子中提取的一种重要化合物。它抑制 L. donovani 前鞭毛体，一种危及生命的内脏利什曼病的病原体的生长^[1]^[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

在强迫游泳试验 (FST) 和悬尾试验 (TST) 中，三种剂量（10、20 和 30 mg/kg）下，Beta-Sitosterol (β-sitosterol) 处理显著缩短了不动时间，表明具有抗抑郁作用。这种效果与剂量为 30 mg/kg 的阳性对照fluoxetine 相似，与对照组相比观察到的效果最强 (P < 0.001)。在 TST 中观察到三种剂量的 Beta-Sitosterol 具有相同的效果。% DID 值如下： FST：39.27%（10 mg/kg）、51.23%（20 mg/kg）和 57.48%（30 mg/kg）； TST：31.63%（10 mg/kg）、43.95%（20 mg/kg）和 53.38%（30 mg/kg）。这些结果表明，Beta-Sitosterol 在 FST 和 TST 期间对小鼠具有显着的抗抑郁活性。此外，Beta-Sitosterol 以剂量依赖的方式表现出抗抑郁作用^[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

414.71

Formula

C₂₉H₅₀O

CAS 号

83-46-5

性状

固体

颜色

White to off-white

中文名称

β-谷甾醇；谷固醇；谷甾醇；麦固醇

结构分类

Steroids

初始来源

内源性代谢物

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶解性数据

In Vitro:

Ethanol 中的溶解度 : 3.85 mg/mL (9.28 mM; 超声助溶)

H₂O 中的溶解度 : < 0.1 mg/mL (insoluble)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.4113 mL	12.0566 mL	24.1132 mL
5 mM	0.4823 mL	2.4113 mL	4.8226 mL
10 mM	---	---	---

查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

摩尔计算器
稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

浓度 _(start)

体积 _(start)

浓度 _(final)

体积 _(final)

In Vivo:

以下溶解方案，请直接配置工作液。建议现用现配，在短期内尽快用完。以下溶剂前显示的百分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶。

方案一

请依序添加每种溶剂： 0.5% CMC-Na/saline water
Solubility: 20 mg/mL (48.23 mM); 悬浊液; 超声助溶

动物溶解方案计算器

请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

每只动物的给药体积

μL

动物数量

只

由于实验过程有损耗，建议您多配一只动物的量

计算结果

工作液所需浓度 : mg/mL

纯度 & 产品资料

纯度: ≥98.0%

选择批次：

Data Sheet (623 KB) SDS (252 KB)

COA (194 KB) HNMR (287 KB)

产品使用指南 (1538 KB)

参考文献

[1]. Bin Sayeed MS, et al. Beta-Sitosterol: A Promising but Orphan Nutraceutical to Fight Against Cancer. Nutr Cancer. 2015;67(8):1214-20. [Content Brief]

[2]. Tariq A, et al. Ethnomedicines and anti-parasitic activities of Pakistani medicinal plants against Plasmodia and Leishmania parasites. Ann Clin Microbiol Antimicrob. 2016 Sep 20;15(1):52. [Content Brief]

[3]. Zhao D, et al. Structural Features and Potent Antidepressant Effects of Total Sterols and β-sitosterol Extracted from Sargassum horneri. Mar Drugs. 2016 Jun 28;14(7). [Content Brief]

Animal Administration ^[3]	Mice^[3] Male ICR mice (20±2 g) and male KunMing mice (20±2 g) are used. Local breed, male ICR mice (20±2 g) are used in the FST under standard conditions with free access to food and water. Mice are randomly divided into four groups (8 mice per group are used) for the tail suspension test (TST): Beta-Sitosterol (10, 20, and 30 mg/kg), total sterols (50, 100, and 200 mg/kg), fluoxetine (20 mg/kg), or distilled water. 80 male mice are used. Briefly, the vehicle or test drugs are administered 30 min before a test session acute ip injection. Then, mice are individually suspended by tail with clamp (2 cm from the tip of the end) in a box (25 cm×25 cm×30 cm) with the head 5 cm to the bottom. Testing is carried out in a darkened room with minimal background noise. All animals are suspended for total 6 min, and the duration of immobility is observed and measured during the final 4-min interval of the test. All test sessions are recorded by a video camera positioned directly above the box. Two competent observers blind to treatment scored the videotapes. Mice consider immobile only when they hung passively and completely motionless. The animals are used only once in this test. All TSTs are performed between 11:00 A.M. and 14:00 P.M. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献	[1]. Bin Sayeed MS, et al. Beta-Sitosterol: A Promising but Orphan Nutraceutical to Fight Against Cancer. Nutr Cancer. 2015;67(8):1214-20. [Content Brief] [2]. Tariq A, et al. Ethnomedicines and anti-parasitic activities of Pakistani medicinal plants against Plasmodia and Leishmania parasites. Ann Clin Microbiol Antimicrob. 2016 Sep 20;15(1):52. [Content Brief] [3]. Zhao D, et al. Structural Features and Potent Antidepressant Effects of Total Sterols and β-sitosterol Extracted from Sargassum horneri. Mar Drugs. 2016 Jun 28;14(7). [Content Brief]

Animal Administration
^[3]

Mice^[3]
Male ICR mice (20±2 g) and male KunMing mice (20±2 g) are used. Local breed, male ICR mice (20±2 g) are used in the FST under standard conditions with free access to food and water. Mice are randomly divided into four groups (8 mice per group are used) for the tail suspension test (TST): Beta-Sitosterol (10, 20, and 30 mg/kg), total sterols (50, 100, and 200 mg/kg), fluoxetine (20 mg/kg), or distilled water. 80 male mice are used. Briefly, the vehicle or test drugs are administered 30 min before a test session acute ip injection. Then, mice are individually suspended by tail with clamp (2 cm from the tip of the end) in a box (25 cm×25 cm×30 cm) with the head 5 cm to the bottom. Testing is carried out in a darkened room with minimal background noise. All animals are suspended for total 6 min, and the duration of immobility is observed and measured during the final 4-min interval of the test. All test sessions are recorded by a video camera positioned directly above the box. Two competent observers blind to treatment scored the videotapes. Mice consider immobile only when they hung passively and completely motionless. The animals are used only once in this test. All TSTs are performed between 11:00 A.M. and 14:00 P.M.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

参考文献

[1]. Bin Sayeed MS, et al. Beta-Sitosterol: A Promising but Orphan Nutraceutical to Fight Against Cancer. Nutr Cancer. 2015;67(8):1214-20. [Content Brief]

[2]. Tariq A, et al. Ethnomedicines and anti-parasitic activities of Pakistani medicinal plants against Plasmodia and Leishmania parasites. Ann Clin Microbiol Antimicrob. 2016 Sep 20;15(1):52. [Content Brief]

[3]. Zhao D, et al. Structural Features and Potent Antidepressant Effects of Total Sterols and β-sitosterol Extracted from Sargassum horneri. Mar Drugs. 2016 Jun 28;14(7). [Content Brief]

Beta-Sitosterol (purity>80%) 相关分类

完整储备液配制表

可选溶剂	浓度溶剂体积质量	1 mg	5 mg	10 mg	25 mg

Ethanol	1 mM	2.4113 mL	12.0566 mL	24.1132 mL	60.2831 mL
Ethanol	5 mM	0.4823 mL	2.4113 mL	4.8226 mL	12.0566 mL

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Beta-Sitosterol (purity>80%) (Synonyms: 谷甾醇; β-Sitosterol (purity>80%); 22,23-Dihydrostigmasterol (purity>80%))

Customer Review

Other Forms of Beta-Sitosterol (purity>80%):

MCE 顾客使用本产品发表的 5 篇科研文献

Beta-Sitosterol (purity>80%) 相关产品

•相关化合物库:

•同靶点产品:

•同靶点蛋白产品:

生物活性

实验参考方法

纯度 & 产品资料

参考文献

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稀释计算器

Beta-Sitosterol (purity>80%) 相关分类

完整储备液配制表

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Beta-Sitosterol (purity>80%) (Synonyms: 谷甾醇; β-Sitosterol (purity>80%); 22,23-Dihydrostigmasterol (purity>80%))

Customer Review

Other Forms of Beta-Sitosterol (purity>80%):

Beta-Sitosterol (purity>80%) 相关抗体

MCE 顾客使用本产品发表的 5 篇科研文献

Beta-Sitosterol (purity>80%) 相关产品

•相关化合物库:

•同靶点产品:

•同靶点蛋白产品:

生物活性

实验参考方法

纯度 & 产品资料

参考文献

Beta-Sitosterol (purity>80%) 相关抗体:

摩尔计算器

稀释计算器

Beta-Sitosterol (purity>80%) 相关分类

完整储备液配制表

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