2. Academic Validation
  3. Sulfonate chalcone as new class voltage-dependent K+ channel blocker

Sulfonate chalcone as new class voltage-dependent K+ channel blocker

  • Bioorg Med Chem Lett. 2008 Jan 1;18(1):137-40. doi: 10.1016/j.bmcl.2007.10.114.
Oleg V Yarishkin 1,  Hyung Won Ryu,  Jae-Yong Park,  Min Suk Yang,  Seong-Geun Hong,  Ki Hun Park
Affiliations

Affiliation

  • 1 Department of Physiology, School of Medicine and Institute of Health Science, Gyeongsang National University, Jinju 660-701, Republic of Korea.
PMID: 18032041 DOI: 10.1016/j.bmcl.2007.10.114
Abstract

Chalcone derivatives 1-17 were synthesized and their voltage-dependent K+ channel inhibitory activities were investigated. The effective K+ channel blockers were shown to be sulfonate Chalcones 9-17, in which the sulfonyloxy group is placed on the A-ring. The 3'-(p-aminobenzene-sulfonylhydroxy)-4-hydroxychalcone 17 (IC50 = 0.51+/-0.05 microM) was the most potent K+ channel blocker.

Figures
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z