2. Academic Validation
  3. Synthesis of glycose carbamides and evaluation of the induction of erythroid differentiation of human erythroleukemic K562 cells

Synthesis of glycose carbamides and evaluation of the induction of erythroid differentiation of human erythroleukemic K562 cells

  • Eur J Med Chem. 2009 Feb;44(2):745-54. doi: 10.1016/j.ejmech.2008.05.001.
Martina Landi 1,  Giorgio Catelani,  Felicia D'Andrea,  Eleonora Ghidini,  Gabriele Amari,  Puccini Paola,  Nicoletta Bianchi,  Roberto Gambari
Affiliations

Affiliation

  • 1 Dipartimento di Chimica Bioorganica e Biofarmacia, Università di Pisa, Via Bonanno 33, I-56126 Pisa, Italy.
PMID: 18571290 DOI: 10.1016/j.ejmech.2008.05.001
Abstract

A series of carbamides derived from 1,2:5,6-di-O-isopropylidene-D-gluco- and D-allofuranose as well as their 5,6-O-deprotected analogues (2 and 4) and methyl 3,4-O-isopropylidene-alpha- and beta-D-galactopyranosides (5 and 6) have been prepared in order to evaluate their ability to induce erythroid differentiation of human erythroleukemic K562 cells. Twenty out of 51 carbamides tested exhibit an appreciable activity as inducers of erythroid differentiation and have been fully characterized and described.

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