2. Academic Validation
  3. Synthesis and DNA-binding properties of polyamine analogues

Synthesis and DNA-binding properties of polyamine analogues

  • J Med Chem. 1991 Aug;34(8):2414-20. doi: 10.1021/jm00112a016.
M L Edwards 1,  R D Snyder,  D M Stemerick
Affiliations

Affiliation

  • 1 Marion Merrell Dow Research Institute, Cincinnati, Ohio 45215.
PMID: 1875339 DOI: 10.1021/jm00112a016
Abstract

The synthesis of a series of novel polyamine analogues is reported. The DNA binding of these compounds and a variety of Other polyamines were compared with their IC50 values against HeLa cell. There seemed to be no apparent correlation between the DNA binding and toxicity against HeLa cells.

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