2. Academic Validation
  3. Morpholine containing CB2 selective agonists

Morpholine containing CB2 selective agonists

  • Bioorg Med Chem Lett. 2009 Mar 15;19(6):1604-9. doi: 10.1016/j.bmcl.2009.02.033.
Renée Zindell 1,  Doris Riether,  Todd Bosanac,  Angela Berry,  Mark J Gemkow,  Andreas Ebneth,  Sabine Löbbe,  Ernest L Raymond,  Diane Thome,  Daw-Tsun Shih,  David Thomson
Affiliations

Affiliation

  • 1 Department of Medicinal Chemistry, Boehringer Ingelheim Pharmaceuticals, Inc., 900 Ridgebury Road, PO Box 368, Ridgefield, CT 06877-0368, USA.
PMID: 19243942 DOI: 10.1016/j.bmcl.2009.02.033
Abstract

Identification and optimization of two classes of CB2 selective agonists are described. A representative from each class is profiled in a murine model of inflammation and each shows similar efficacy to prednisolone upon oral dosing.

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