2. Academic Validation
  3. Hair growth stimulator property of thienyl substituted pyrazole carboxamide derivatives as a CB1 receptor antagonist with in vivo antiobesity effect

Hair growth stimulator property of thienyl substituted pyrazole carboxamide derivatives as a CB1 receptor antagonist with in vivo antiobesity effect

  • Bioorg Med Chem Lett. 2009 May 1;19(9):2546-50. doi: 10.1016/j.bmcl.2009.03.046.
Brijesh Kumar Srivastava 1,  Rina Soni,  Jayendra Z Patel,  Amit Joharapurkar,  Nisha Sadhwani,  Samadhan Kshirsagar,  Bhupendra Mishra,  Vijay Takale,  Sunil Gupta,  Purvi Pandya,  Prashant Kapadnis,  Manish Solanki,  Harilal Patel,  Prasenjit Mitra,  Mukul R Jain,  Pankaj R Patel
Affiliations

Affiliation

  • 1 Department of Medicinal Chemistry, Zydus Research Centre, Sarkhej-Bavla N. H. 8A, Moraiya, Ahmedabad 382 210, India.
PMID: 19328683 DOI: 10.1016/j.bmcl.2009.03.046
Abstract

A few thienyl substituted pyrazole derivatives were synthesized to aid in the characterization of the Cannabinoid Receptor antagonist and also to serve as potentially useful antiobesity agent. Structural requirements for selective CB1 receptor antagonistic activity of 5-thienyl pyrazole derivatives included the structural similarity with potent, specific antagonist rimonabant 1. Compound 3 has been identified as a hair growth stimulator and an antiobesity agent in animal models.

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