2. Academic Validation
  3. The discovery of novel calcium sensing receptor negative allosteric modulators

The discovery of novel calcium sensing receptor negative allosteric modulators

  • Bioorg Med Chem Lett. 2009 Jun 15;19(12):3328-32. doi: 10.1016/j.bmcl.2009.04.044.
Gayatri Balan 1,  Jonathan Bauman,  Samit Bhattacharya,  Mayda Castrodad,  David R Healy,  Michael Herr,  Paul Humphries,  Sandra Jennings,  Amit S Kalgutkar,  Brendon Kapinos,  Vishal Khot,  Kimberly Lazarra,  Mei Li,  Yan Li,  Constantin Neagu,  Robert Oliver,  David W Piotrowski,  David Price,  Hong Qi,  Holly A Simmons,  James Southers,  Liuqing Wei,  Yan Zhang,  Vishwas M Paralkar
Affiliations

Affiliation

  • 1 Pfizer Global Research and Development, Groton/New London Laboratories, Pfizer Inc., Eastern Point Road, Groton, CT 06340, USA.
PMID: 19442519 DOI: 10.1016/j.bmcl.2009.04.044
Abstract

The design and profile of a series of zwitterionic calcium sensing receptor negative allosteric modulators is described. Evaluation of key analogues using a rat model demonstrate a robust response, significantly improved potency over ronacaleret and have the potential as an oral, anabolic treatment for osteoporosis.

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