2. Academic Validation
  3. Structure-activity relationship studies of targeting ligands against breast cancer cells

Structure-activity relationship studies of targeting ligands against breast cancer cells

  • J Med Chem. 2009 Nov 12;52(21):6744-51. doi: 10.1021/jm9012032.
Nianhuan Yao 1,  Wenwu Xiao,  Leah Meza,  Harry Tseng,  Mathida Chuck,  Kit S Lam
Affiliations

Affiliation

  • 1 Division of Hematology and Oncology, Department of Internal Medicine, UC Davis Cancer Center, University of California Davis, Sacramento, California 95817, USA.
PMID: 19835381 DOI: 10.1021/jm9012032
Abstract

A series of LXY3 (1) analogues were designed and synthesized. Their binding affinity was demonstrated using MDA-MB-231 breast Cancer cells adherence inhibition assay. Further structure-activity relationship was obtained. Analogue 29 was discovered to have 3.5-fold increase of the binding affinity. Fluorescent microscopy and in vivo and ex vivo imaging studies demonstrated that 29 is an efficient in vivo targeting agent against alpha3 Integrin of MDA-MB-231 breast tumor xenograft implant.

Figures
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z