2. Academic Validation
  3. Synthesis and biological evaluation of piperazinyl carbamates and ureas as fatty acid amide hydrolase (FAAH) and transient receptor potential (TRP) channel dual ligands

Synthesis and biological evaluation of piperazinyl carbamates and ureas as fatty acid amide hydrolase (FAAH) and transient receptor potential (TRP) channel dual ligands

  • Bioorg Med Chem Lett. 2009 Dec 1;19(23):6806-9. doi: 10.1016/j.bmcl.2009.09.033.
Enrico Morera 1,  Luciano De Petrocellis,  Ludovica Morera,  Aniello Schiano Moriello,  Alessia Ligresti,  Marianna Nalli,  David F Woodward,  Vincenzo Di Marzo,  Giorgio Ortar
Affiliations

Affiliation

  • 1 Dipartimento di Chimica e Tecnologie del Farmaco, Sapienza Università di Roma, 00185 Roma, Italy.
PMID: 19875281 DOI: 10.1016/j.bmcl.2009.09.033
Abstract

The evaluation of a series of piperazinyl carbamates and ureas, designed on the basis of previously reported TRPV1 antagonists and FAAH inhibitors, led to the identification of some 'dual-action' compounds targeting both FAAH and TRPV1 or TRPA1 receptors.

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