2. Academic Validation
  3. Bi-linderone, a highly modified methyl-linderone dimer from Lindera aggregata with activity toward improvement of insulin sensitivity in vitro

Bi-linderone, a highly modified methyl-linderone dimer from Lindera aggregata with activity toward improvement of insulin sensitivity in vitro

  • Org Lett. 2010 May 21;12(10):2354-7. doi: 10.1021/ol1007247.
Fei Wang 1,  Yuan Gao,  Ling Zhang,  Ji-Kai Liu
Affiliations

Affiliation

  • 1 State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, People's Republic of China.
PMID: 20420414 DOI: 10.1021/ol1007247
Abstract

Bi-linderone (1) was isolated as racemate from the traditional Chinese medicinal plant Lindera aggregata. The structure elucidation of bi-linderone was reported on the basis of extensive analysis of NMR spectra and crystal X-ray diffraction. Bi-linderone has an unprecedented spirocyclopentenedione-containing carbon skeleton and showed significant activity against glucosamine-induced Insulin resistance in HepG2 cells at a concentration of 1 microg/mL.

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