2. Academic Validation
  3. Structure-activity relationship of indoline-2-carboxylic acid N-(substituted)phenylamide derivatives

Structure-activity relationship of indoline-2-carboxylic acid N-(substituted)phenylamide derivatives

  • Bioorg Med Chem Lett. 2010 Aug 1;20(15):4620-3. doi: 10.1016/j.bmcl.2010.06.004.
Jae-Hwan Kwak 1,  Yoseob Kim,  Hyunjeong Park,  Jae-Yong Jang,  Keun Kuk Lee,  Wonhui Yi,  Jeong-Ah Kwak,  Song-Gyu Park,  Hwanmook Kim,  Kiho Lee,  Jong Soon Kang,  Sang-Bae Han,  Bang Yeon Hwang,  Jin Tae Hong,  Jae-Kyung Jung,  Youngsoo Kim,  Jungsook Cho,  Heesoon Lee
Affiliations

Affiliation

  • 1 Department of Pharmacy, Chungbuk National University, Chungbuk, Republic of Korea.
PMID: 20579876 DOI: 10.1016/j.bmcl.2010.06.004
Abstract

Chroman derivatives exhibited potent inhibitory activity of NF-kappaB. For SAR, the chroman scaffold was modified with an indoline moiety. A series of indoline-2-carboxylic acid N-(substituted)phenylamide derivatives were synthesized to explore their inhibitory activities of NF-kappaB and they were also evaluated for cytotoxicity against various Cancer cell lines. Since intermediates with Boc showed outstanding results, various substituents in place of the Boc group were introduced additionally and these compounds were also evaluated for SAR.

Figures
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z