2. Academic Validation
  3. Antitumor Agents. 282. 2'-(R)-O-acetylglaucarubinone, a quassinoid from Odyendyea gabonensis as a potential anti-breast and anti-ovarian cancer agent

Antitumor Agents. 282. 2'-(R)-O-acetylglaucarubinone, a quassinoid from Odyendyea gabonensis as a potential anti-breast and anti-ovarian cancer agent

  • J Nat Prod. 2010 Sep 24;73(9):1553-8. doi: 10.1021/np100406d.
Yoshihide Usami 1,  Kyoko Nakagawa-Goto,  Jing-Yu Lang,  Yoon Kim,  Chin-Yu Lai,  Masuo Goto,  Nobuko Sakurai,  Masahiko Taniguchi,  Toshiyuki Akiyama,  Susan L Morris-Natschke,  Kenneth F Bastow,  Gordon Cragg,  David J Newman,  Mihoyo Fujitake,  Koichi Takeya,  Mien-Chie Hung,  Eva Y-H P Lee,  Kuo-Hsiung Lee
Affiliations

Affiliation

  • 1 Natural Products Research Laboratories, Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, North Carolina 27599-7568, USA.
PMID: 20738103 DOI: 10.1021/np100406d
Abstract

A new quassinoid, designated 2'-(R)-O-acetylglaucarubinone (1), and seven known quassinoids (2-8) were isolated, using bioactivity-guided separation, from the bark of Odyendyea gabonensis (Pierre) Engler [syn. Quassia gabonensis Pierre]. The structure of 1 was determined by spectroscopic analysis and by semisynthesis from glaucarubolone. Complete (1)H and (13)C NMR assignments of compounds 1-8 were also established from detailed analysis of two-dimensional NMR spectra, and the reported configurations in odyendene (7) and odyendane (8) were corrected. Compound 1 showed potent cytotoxicity against multiple Cancer cell lines. Further investigation using various types of breast and ovarian Cancer cell lines suggested that 1 does not target the Estrogen receptor or Progesterone Receptor. When tested against mammary epithelial proliferation in vivo using a Brca1/p53-deficient mice model, 1 also caused significant reduction in mammary duct branching.

Figures
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z