2. Academic Validation
  3. Synthesis and biological activity of some antitumor active derivatives from glycyrrhetinic acid

Synthesis and biological activity of some antitumor active derivatives from glycyrrhetinic acid

  • Eur J Med Chem. 2010 Dec;45(12):5718-23. doi: 10.1016/j.ejmech.2010.09.028.
René Csuk 1,  Stefan Schwarz,  Ralph Kluge,  Dieter Ströhl
Affiliations

Affiliation

  • 1 Bereich Organische Chemie, Martin-Luther-Universität Halle-Wittenberg, Kurt-Mothes-Str. 2, D-06120 Halle, Saale, Germany. rene.csuk@chemie.uni-halle.de
PMID: 20884085 DOI: 10.1016/j.ejmech.2010.09.028
Abstract

Aminoalkyl substituted derivatives were synthesized starting from glycyrrhetinic acid methyl ester and screened for antitumor activity in a panel of 15 human Cancer cell lines by an SRB assay. The most compound 7 possesses an aminohexyl side chain, induces Apoptosis and shows IC50 values of 0.6-3.0 μM.

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