2. Academic Validation
  3. α-Tocotrienol quinone modulates oxidative stress response and the biochemistry of aging

α-Tocotrienol quinone modulates oxidative stress response and the biochemistry of aging

  • Bioorg Med Chem Lett. 2011 Jun 15;21(12):3693-8. doi: 10.1016/j.bmcl.2011.04.085.
William D Shrader 1,  Akiko Amagata,  Adam Barnes,  Gregory M Enns,  Andrew Hinman,  Orion Jankowski,  Viktoria Kheifets,  Ryo Komatsuzaki,  Edgar Lee,  Paul Mollard,  Katsuyuki Murase,  Alfredo A Sadun,  Martin Thoolen,  Kieron Wesson,  Guy Miller
Affiliations

Affiliation

  • 1 Edison Pharmaceuticals, Inc., Mountain View, CA 94043, USA. bshrader@edisonpharma.com
PMID: 21600768 DOI: 10.1016/j.bmcl.2011.04.085
Abstract

We report that α-tocotrienol quinone (ATQ3) is a metabolite of α-tocotrienol, and that ATQ3 is a potent cellular protectant against oxidative stress and aging. ATQ3 is orally bioavailable, crosses the blood-brain barrier, and has demonstrated clinical response in inherited mitochondrial disease in open label studies. ATQ3 activity is dependent upon reversible 2e-redox-cycling. ATQ3 may represent a broader class of unappreciated dietary-derived phytomolecular redox motifs that digitally encode biochemical data using redox state as a means to sense and transfer information essential for cellular function.

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