2. Academic Validation
  3. Synthesis and anti-HCMV activity of 1-[ω-(phenoxy)alkyl]uracil derivatives and analogues thereof

Synthesis and anti-HCMV activity of 1-[ω-(phenoxy)alkyl]uracil derivatives and analogues thereof

  • Bioorg Med Chem. 2013 Jul 15;21(14):4151-7. doi: 10.1016/j.bmc.2013.05.009.
Mikhail S Novikov 1,  Denis A Babkov,  Maria P Paramonova,  Anastasia L Khandazhinskaya,  Alexander A Ozerov,  Alexander O Chizhov,  Graciela Andrei,  Robert Snoeck,  Jan Balzarini,  Katherine L Seley-Radtke
Affiliations

Affiliation

  • 1 Department of Pharmaceutical & Toxicological Chemistry, Volgograd State Medical University, Pavshikh Bortsov Sq., 1, Volgograd 400131, Russia.
PMID: 23743443 DOI: 10.1016/j.bmc.2013.05.009
Abstract

HCMV Infection represents a life-threatening condition for immunocompromised patients and newborn infants and novel anti-HCMV agents are clearly needed. In this regard, a series of 1-[ω-(phenoxy)alkyl]uracil derivatives were synthesized and examined for Antiviral properties. Compounds 17, 20, 24 and 28 were found to exhibit highly specific and promising inhibitory activity against HCMV replication in HEL cell cultures with EC50 values within 5.5-12μM range. Further studies should be undertaken to elucidate the mechanism of action of these compounds and the structure-activity relationship for the linker region.

Figures
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z