2. Academic Validation
  3. Antineoplastic agents, 107. Isolation of acteoside and isoacteoside from Castilleja linariaefolia

Antineoplastic agents, 107. Isolation of acteoside and isoacteoside from Castilleja linariaefolia

  • J Nat Prod. 1990 Mar-Apr;53(2):456-8. doi: 10.1021/np50068a026.
G R Pettit 1,  A Numata,  T Takemura,  R H Ode,  A S Narula,  J M Schmidt,  G M Cragg,  C P Pase
Affiliations

Affiliation

  • 1 Cancer Research Institute, Arizona State University, Tempe 85287.
PMID: 2380718 DOI: 10.1021/np50068a026
Abstract

The southwestern Indian paintbrush, Castilleja linariaefolia, yielded extracts that displayed in vivo activity against murine P-388 (PS) lymphocytic leukemia. Separation guided by PS cell line inhibition led to isolation of cytotoxic compounds that were identified as the known glycosides acteoside [1] (ED50 2.6 micrograms/ml) and isoacteoside [2] (ED50 10 micrograms/ml). The identifications were established by spectral measurements and degradation studies. Mannitol was also found in this plant.

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