2. Academic Validation
  3. Synthesis and biological evaluation of caffeic acid derivatives as potent inhibitors of α-MSH-stimulated melanogenesis

Synthesis and biological evaluation of caffeic acid derivatives as potent inhibitors of α-MSH-stimulated melanogenesis

  • Bioorg Med Chem Lett. 2017 Aug 1;27(15):3374-3377. doi: 10.1016/j.bmcl.2017.06.011.
Hyeju Jo 1,  Minho Choi 1,  Jaeuk Sim 1,  Mayavan Viji 1,  Siyuan Li 1,  Young Hee Lee 1,  Youngsoo Kim 1,  Seung-Yong Seo 2,  Yuanyuan Zhou 3,  Kiho Lee 3,  Wun-Jae Kim 4,  Jin Tae Hong 1,  Heesoon Lee 1,  Jae-Kyung Jung 5
Affiliations

Affiliations

  • 1 College of Pharmacy and Medicinal Research Center (MRC), Chungbuk National University, Cheongju 28160, Republic of Korea.
  • 2 College of Pharmacy and Gachon Institute of Pharmaceutical Sciences, Gachon University, Incheon 21936, Republic of Korea. Electronic address: syseo@gachon.ac.kr.
  • 3 College of Pharmacy, Korea University, Sejong 30019, Republic of Korea.
  • 4 College of Medicines, Chungbuk National University, Cheongju 28644, Republic of Korea.
  • 5 College of Pharmacy and Medicinal Research Center (MRC), Chungbuk National University, Cheongju 28160, Republic of Korea. Electronic address: orgjkjung@chungbuk.ac.kr.
PMID: 28619537 DOI: 10.1016/j.bmcl.2017.06.011
Abstract

We have disclosed our effort to develop caffeic acid derivatives as potent and non-toxic inhibitors of α-MSH-stimulated melanogenesis to treat pigmentation disorders and skin medication including a cosmetic skin-whitening agent. The SAR studies revealed that cyclohexyl ester and secondary amide derivatives of caffeic acid showed significant inhibitory activities.

Keywords

Caffeamide; Caffeic acid; Melanogenesis; Skin whitening; α-MSH.

Figures
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z