2. Academic Validation
  3. Histone deacetylase inhibitor, AR-42, exerts antitumor effects by inducing apoptosis and cell cycle arrest in Y79 cells

Histone deacetylase inhibitor, AR-42, exerts antitumor effects by inducing apoptosis and cell cycle arrest in Y79 cells

  • J Cell Physiol. 2019 Dec;234(12):22411-22423. doi: 10.1002/jcp.28806.
Sujuan Duan 1 2,  Xiaona Gong 3,  Xing Liu 4,  Wenwen Cui 4,  Kaddie Chen 2,  Longbing Mao 4,  Sun Jun 5,  Ruihao Zhou 4,  Yi Sang 2,  Guofu Huang 1 2
Affiliations

Affiliations

  • 1 Department of Ophthalmology, The Third Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, People's Republic of China.
  • 2 Jiangxi Key Laboratory of Cancer Metastasis and Precision Treatment, The Third Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, People's Republic of China.
  • 3 Department of Ophthalmology, Xiangyang First People's Hospital, Xiangyang, China.
  • 4 Medical Department of Graduate School, Nanchang University, Nanchang, Jiangxi, People's Republic of China.
  • 5 First Clinical Department, Medical School of Nanchang University, Nanchang, Jiangxi, People's Republic of China.
PMID: 31102271 DOI: 10.1002/jcp.28806
Abstract

Retinoblastoma (RB) is the most common type of intraocular malignant tumor that occurs in childhood. AR-42, a member of a newly discovered class of phenylbutyrate-derived histone deacetylase inhibitors, exerts antitumor effects on many cancers. In the present study, we initially evaluated the effect of AR-42 towards RB cells and explored the underlying mechanism in this disease. Our results found that AR-42 showed powerful antitumor effects at low micromolar concentrations by inhibiting cell viability, blocking cell cycle, stimulating Apoptosis in vitro, and suppressing RB growth in a mouse subcutaneous tumor xenograft model. Furthermore, the Akt/nuclear factor-kappa B signaling pathway was disrupted in Y79 cells treated with AR-42. In conclusion, we propose that AR-42 might be a promising drug treatment for RB.

Keywords

AKT/NF-κB; AR-42; Y79; retinoblastoma.

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