2. Academic Validation
  3. Anticancer saponin OSW-1 is a novel class of selective Golgi stress inducer

Anticancer saponin OSW-1 is a novel class of selective Golgi stress inducer

  • Bioorg Med Chem Lett. 2019 Jul 15;29(14):1732-1736. doi: 10.1016/j.bmcl.2019.05.022.
Mayu Kimura 1,  Kanae Sasaki 2,  Yosuke Fukutani 1,  Hiderou Yoshida 2,  Ikuroh Ohsawa 3,  Masafumi Yohda 1,  Kaori Sakurai 4
Affiliations

Affiliations

  • 1 Department of Biotechnology and Life Science, Faculty of Engineering, Tokyo University of Agriculture and Technology, 2-24-18, Naka-cho, Koganei-shi, Tokyo 184-8588, Japan.
  • 2 Department of Biochemistry and Molecular Biology, Graduate School of Life Science, University of Hyogo, Harima Science Garden City, Hyogo 678-1297, Japan.
  • 3 Biological Process of Aging, Tokyo Metropolitan Institute of Gerontology, 35-2 Sakae-cho, Itabashi-ku, Tokyo 173-0015, Japan.
  • 4 Department of Biotechnology and Life Science, Faculty of Engineering, Tokyo University of Agriculture and Technology, 2-24-18, Naka-cho, Koganei-shi, Tokyo 184-8588, Japan. Electronic address: sakuraik@cc.tuat.ac.jp.
PMID: 31126855 DOI: 10.1016/j.bmcl.2019.05.022
Abstract

OSW-1 is a plant-derived natural product proposed to selectively kill Cancer cells by binding to members of the oxysterol binding protein family, thereby disrupting lipid/sterol homeostasis. However, how these protein-ligand interactions mediate cell death signaling has remained elusive. Here, we discovered that OSW-1 selectively activates the Golgi stress response leading to Apoptosis, providing a mechanistic basis for the Anticancer activity of OSW-1.

Keywords

Anticancer natural product; Golgi stress response; OSBP; OSW-1; Saponin.

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