2. Academic Validation
  3. Celastrol: Progresses in structure-modifications, structure-activity relationships, pharmacology and toxicology

Celastrol: Progresses in structure-modifications, structure-activity relationships, pharmacology and toxicology

  • Eur J Med Chem. 2020 Mar 1:189:112081. doi: 10.1016/j.ejmech.2020.112081.
Wei Hou 1,  Bo Liu 2,  Hongtao Xu 3
Affiliations

Affiliations

  • 1 College of Pharmaceutical Science and Institute of Drug Development & Chemical Biology (IDD & CB), Zhejiang University of Technology, Hangzhou, China. Electronic address: houwei@zjut.edu.cn.
  • 2 The Second Clinical Medical College, And Guangdong Provincial Key Laboratory of Clinical Research on Traditional Chinese Medicine Syndrome, Guangzhou University of Chinese Medicine, Guangzhou, China. Electronic address: doctliu@gzucm.edu.cn.
  • 3 Shanghai Institute for Advanced Immunochemical Studies, ShanghaiTech University, Shanghai, China. Electronic address: xuht@shanghaitech.edu.cn.
PMID: 31991334 DOI: 10.1016/j.ejmech.2020.112081
Abstract

Celastrol, a principal bioactive ingredient of Tripterygium wilfordii Hook F, has gained extensive exploration due to its unique structure features and multiple promising biological activities. This review will focus on the structural modifications, structure-activity relationships, pharmacology, and toxicology of celastrol in the past ten years. We hope this review would be helpful to get a better grasp of the progresses in the field and provide constructive suggestions for the further study of celastrol.

Keywords

Cancer; Celastrol; Diabetes; Inflammatory; Medicinal chemistry; Obese; Pharmacology and toxicology; Toxicity; Tripterygium wilfordii hook F..

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