2. Academic Validation
  3. A potently neutralizing anti-SARS-CoV-2 antibody inhibits variants of concern by binding a highly conserved epitope

A potently neutralizing anti-SARS-CoV-2 antibody inhibits variants of concern by binding a highly conserved epitope

  • bioRxiv. 2021 Apr 26:2021.04.26.441501. doi: 10.1101/2021.04.26.441501.
Laura VanBlargan,  Lucas Adams,  Zhuoming Liu,  Rita E Chen,  Pavlo Gilchuk,  Saravanan Raju,  Brittany Smith,  Haiyan Zhao,  James Brett Case,  Emma S Winkler,  Bradley Whitener,  Lindsay Droit,  Ismael Aziati,  Pei-Yong Shi,  Adrian Creanga,  Amarendra Pegu,  Scott Handley,  David Wang,  Adrianus Boon,  James E Crowe,  Sean P J Whelan,  Daved Fremont,  Michael Diamond
PMID: 33907753 DOI: 10.1101/2021.04.26.441501
Abstract

With the emergence of SARS-CoV-2 variants with increased transmissibility and potential resistance, antibodies and vaccines with broadly inhibitory activity are needed. Here we developed a panel of neutralizing anti-SARS-CoV-2 mAbs that bind the receptor binding domain of the spike protein at distinct epitopes and block virus attachment to cells and its receptor, human angiotensin converting enzyme-2 (hACE2). While several potently neutralizing mAbs protected K18-hACE2 transgenic mice against Infection caused by historical SARS-CoV-2 strains, Others induced escape variants in vivo and lost activity against emerging strains. We identified one mAb, SARS2-38, that potently neutralizes all SARS-CoV-2 variants of concern tested and protects mice against challenge by multiple SARS-CoV-2 strains. Structural analysis showed that SARS2-38 engages a conserved epitope proximal to the receptor binding motif. Thus, treatment with or induction of inhibitory antibodies that bind conserved spike epitopes may limit the loss of potency of therapies or vaccines against emerging SARS-CoV-2 variants.

Figures
Products
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z