2. Academic Validation
  3. Oxidative stress and DNA damage induced by trifloxystrobin on earthworms (Eisenia fetida) in two soils

Oxidative stress and DNA damage induced by trifloxystrobin on earthworms (Eisenia fetida) in two soils

  • Sci Total Environ. 2021 Nov 25:797:149004. doi: 10.1016/j.scitotenv.2021.149004.
Ruolin Wu 1,  Tongtong Zhou 1,  Jun Wang 2,  Jinhua Wang 3,  Zhongkun Du 4,  Bing Li 1,  Albert Juhasz 5,  Lusheng Zhu 6
Affiliations

Affiliations

  • 1 College of Resources and Environment, Shandong Agricultural University, Key Laboratory of Agricultural Environment in Universities of Shandong, 61 Daizong Road, Taian 271018, China.
  • 2 College of Resources and Environment, Shandong Agricultural University, Key Laboratory of Agricultural Environment in Universities of Shandong, 61 Daizong Road, Taian 271018, China. Electronic address: jwang@sdau.edu.cn.
  • 3 College of Resources and Environment, Shandong Agricultural University, Key Laboratory of Agricultural Environment in Universities of Shandong, 61 Daizong Road, Taian 271018, China. Electronic address: wjh@sdau.edu.cn.
  • 4 College of Resources and Environment, Shandong Agricultural University, Key Laboratory of Agricultural Environment in Universities of Shandong, 61 Daizong Road, Taian 271018, China. Electronic address: dzk66@sdau.edu.cn.
  • 5 Future Industries Institute, University of South Australia, Mawson Lakes, SA 5095, Australia. Electronic address: Albert.Juhasz@unisa.edu.au.
  • 6 College of Resources and Environment, Shandong Agricultural University, Key Laboratory of Agricultural Environment in Universities of Shandong, 61 Daizong Road, Taian 271018, China. Electronic address: lushzhu@sdau.edu.cn.
PMID: 34293608 DOI: 10.1016/j.scitotenv.2021.149004
Abstract

Trifloxystrobin is a new type of fungicide, which is extensively used due to its excellent Antifungal activity. In this study, oxidative stress and DNA damage induced by trifloxystrobin exposure was evaluated using Eisenia fetida at subchronic toxicity concentrations in artificial soil and brown soil (0.1-2.5 mg/kg). Throughout the exposure period (days 7, 28 and 56), six biochemical indicators including Reactive Oxygen Species (ROS), antioxidant enzymes (SOD and CAT), glutathione S-transferase (GST), lipid peroxidation and DNA damage (8-hydroxydeoxyguanosine) were measured. In addition, the integrated biomarker response (IBR) index was calculated to make comparison of toxicological response between artificial and brown soils. Results indicated that trifloxystrobin can induce oxidative stress and DNA damage to earthworms with subchronic toxicity greater in brown soil compared to artificial soil as determined through integrated calculations for six biochemical indicators. Trifloxystrobin toxicological experiments in artificial soil may not accurately evaluate its toxicity in natural soil ecosystems, as the toxicity of trifloxystrobin to Eisenia fetida was underestimated.

Keywords

Antioxidant enzyme; Artificial soil; Brown soil; IBR; Strobilurin fungicide.

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