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  3. Synthesis and application of small molecules approved for the treatment of lymphoma

Synthesis and application of small molecules approved for the treatment of lymphoma

  • Eur J Med Chem. 2023 Dec 5:261:115835. doi: 10.1016/j.ejmech.2023.115835.
Yuan-Yuan Guo 1,  Jing-Yi Zhang 2,  Jin-Feng Sun 3,  Peng Nie 4,  Hua Gao 5
Affiliations

Affiliations

  • 1 Department of Pharmacy, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China; Henan Key Laboratory of Precision Clinical Pharmacy, Zhengzhou University, Zhengzhou, 450052, China.
  • 2 College of Chemistry and Chemical Engineering, Zhengzhou Normal University, 450044, China. Electronic address: zhangjingyi@zznu.edu.cn.
  • 3 Key Laboratory of Natural Medicines of the Changbai Mountain, Ministry of Education, Yanbian University, College of Pharmacy, Yanji, Jilin, 133002, China. Electronic address: jfsun@ybu.edu.cn.
  • 4 Medicinal Chemistry, Rega Institute of Medical Research, KU Leuven, Herestraat 49, 3000, Leuven, Belgium. Electronic address: peng.nie@kuleuven.be.
  • 5 Department of Radiotherapy, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China. Electronic address: gaohua_2008@163.com.
PMID: 37801827 DOI: 10.1016/j.ejmech.2023.115835
Abstract

Lymphoma is a form of Cancer that impacts the lymphatic system, which plays a crucial role in defending the body against infections and illnesses. It is characterized by the atypical proliferation of lymphocytes, a type of white blood cell, which can form tumors in the lymph nodes, bone marrow, spleen, etc. Lymphoma is usually treated using a combination of targeted therapy, chemotherapy, and radiation therapy. In recent years, there has been a growing interest in the development of new drugs to treat lymphoma, which has led to the discovery of several promising compounds. The primary targets for lymphoma treatment have been identified as Bruton's tyrosine kinase (Btk), phosphoinositide3-kinase (PI3K), histone deacetylase (HDAC), and DNA Polymerase (POLA). This review aims to provide an overview of the clinical applications and synthesis of several notable drugs approved to treat lymphoma, to expedite the exploration of more potent novel medications for the management of lymphoma.

Keywords

Clinical applications; Contents; Drugs; Lymphoma; Synthesis.

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