2. Academic Validation
  3. pH regulators and their inhibitors in tumor microenvironment

pH regulators and their inhibitors in tumor microenvironment

  • Eur J Med Chem. 2024 Mar 5:267:116170. doi: 10.1016/j.ejmech.2024.116170.
Senyi Liao 1,  Guang Wu 2,  Zhizhong Xie 1,  Xiaoyong Lei 1,  Xiaoyan Yang 1,  Sheng Huang 3,  Xiangping Deng 4,  Zhe Wang 5,  Guotao Tang 6
Affiliations

Affiliations

  • 1 Institute of Pharmacy and Pharmacology, Hunan Provincial Key Laboratory of Tumor Microenvironment Responsive Drug Research, Hengyang Medical School, University of South China, Hengyang, Hunan, 421001, China.
  • 2 The Second Affiliated Hospital, Department of Pharmacy, Hengyang Medical School, University of South China, Hengyang, 421001, Hunan, China.
  • 3 Jiuzhitang Co., Ltd, Changsha, Hunan, 410007, China.
  • 4 The First Affiliated Hospital, Department of Pharmacy, Hengyang Medical School, University of South China, Hengyang, 421001, Hunan, China. Electronic address: dengxpusc@163.com.
  • 5 The Second Affiliated Hospital, Department of Pharmacy, Hengyang Medical School, University of South China, Hengyang, 421001, Hunan, China. Electronic address: wangz1525@163.com.
  • 6 Institute of Pharmacy and Pharmacology, Hunan Provincial Key Laboratory of Tumor Microenvironment Responsive Drug Research, Hengyang Medical School, University of South China, Hengyang, Hunan, 421001, China. Electronic address: tgtzq@163.com.
PMID: 38308950 DOI: 10.1016/j.ejmech.2024.116170
Abstract

As an important characteristic of tumor, acidic tumor microenvironment (TME) is closely related to immune escape, invasion, migration and drug resistance of tumor. The acidity of the TME mainly comes from the acidic products produced by the high level of tumor metabolism, such as lactic acid and carbon dioxide. pH regulators such as monocarboxylate transporters (MCTs), Carbonic Anhydrase IX (CA IX), and Na+/H+ exchange 1 (NHE1) expel protons directly or indirectly from the tumor to maintain the pH balance of tumor cells and create an acidic TME. We review the functions of several pH regulators involved in the construction of acidic TME, the structure and structure-activity relationship of pH regulator inhibitors, and provide strategies for the development of small-molecule antitumor inhibitors based on these targets.

Keywords

Carbonic anhydrase IX; Monocarboxylate transportors; Na(+)/H(+) exchanger 1; Structure-activity relationship; Tumor microenvironment; pH regulators.

Figures
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z