2. Academic Validation
  3. 3',4',7-trihydroxyflavone activates the CREB-BDNF axis and restores scopolamine-induced memory deficit in mice

3',4',7-trihydroxyflavone activates the CREB-BDNF axis and restores scopolamine-induced memory deficit in mice

  • Eur J Pharmacol. 2025 Jul 15:999:177645. doi: 10.1016/j.ejphar.2025.177645.
Seong-Seop Kim 1,  Won Seok Kim 2,  HyunSeon Moon 3,  Soo-Jin Oh 4,  Gyu-Sang Hong 4,  Bonggi Lee 5,  Chun Whan Choi 6,  Bora Lee 7,  Jae Sue Choi 8,  Min Soo Kim 9
Affiliations

Affiliations

  • 1 Brain Science Institute, Korea Institute of Science and Technology (KIST), Seoul, 02792, Republic of Korea.
  • 2 Brain Science Institute, Korea Institute of Science and Technology (KIST), Seoul, 02792, Republic of Korea; Life Sciences and Biotechnology Division of Life Science, Korea University, Seoul, 02841, Republic of Korea.
  • 3 Brain Science Institute, Korea Institute of Science and Technology (KIST), Seoul, 02792, Republic of Korea; Department of Biotechnology, Yonsei University, Seoul, 03722, Republic of Korea.
  • 4 Brain Science Institute, Korea Institute of Science and Technology (KIST), Seoul, 02792, Republic of Korea; Division of Bio-Medical Science & Technology, KIST School, Korea National University of Science and Technology (UST), Seoul, 02792, Republic of Korea.
  • 5 Department of Food Science and Nutrition, Pukyong National University, Busan, 48513, Republic of Korea.
  • 6 Natural Product Research Team, Gyeonggi Biocenter, Gyeonggi-do Business and Science Accelerator, Suwon, 16229, Republic of Korea.
  • 7 Chonnam National University Medical School, Hwasun, 58128, Republic of Korea. Electronic address: blee03@chonnam.ac.kr.
  • 8 Department of Food Science and Nutrition, Pukyong National University, Busan, 48513, Republic of Korea. Electronic address: choijs@pknu.ac.kr.
  • 9 Brain Science Institute, Korea Institute of Science and Technology (KIST), Seoul, 02792, Republic of Korea; Division of Bio-Medical Science & Technology, KIST School, Korea National University of Science and Technology (UST), Seoul, 02792, Republic of Korea; KHU-KIST Department of Converging Science and Technology, Kyung Hee University, Seoul, 02447, Republic of Korea. Electronic address: minsoo.kim@kist.re.kr.
PMID: 40318820 DOI: 10.1016/j.ejphar.2025.177645
Abstract

Alzheimer's disease is a major neurodegenerative disorder that leads to dementia, yet specific treatments remain elusive. Although Albizzia julibrissin has been used in traditional oriental medicine to treat insomnia and disorientation by its anti-inflammatory properties, there are currently no studies in animal models. This study aims to identify potential therapeutic candidates for Alzheimer's disease by examining how 3',4',7-trihydroxyflavone (THF), isolated from Albizzia julibrissin stem bark, as a potential therapeutic candidate for Alzheimer's disease by examining memory recovery in a scopolamine-induced memory deficit mouse model. THF administration both orally and centrally in scopolamine-induced AD mice led to significant improvements in cognitive performance. Biochemical assays revealed restoration of cholinergic markers (ACh, AChE, ChAT) and an increase in BDNF levels in the hippocampus. Electrophysiological recordings confirmed that THF restored LTP reduced by scopolamine, indicating improved synaptic plasticity. These findings suggest that THF has the potential neuropharmacological agent to protect the brain from memory loss induced by Alzheimer's disease through enhancing cholinergic system activity and activating the CREB-BDNF signaling pathway in the hippocampus.

Keywords

3′,4′,7-trihydroxyflavone; Albizzia julibrissin; Alzheimer's disease; Memory; Scopolamine.

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