2. Academic Validation
  3. Extracellular vesicle-mediated transmission of circPDLIM5 promotes lymphatic metastasis in prostate cancer

Extracellular vesicle-mediated transmission of circPDLIM5 promotes lymphatic metastasis in prostate cancer

  • J Exp Clin Cancer Res. 2025 Jul 3;44(1):188. doi: 10.1186/s13046-025-03443-2.
Tao He # 1 2,  Wen Tao # 3,  Jie Zhang # 4,  Tao-Lin Xia 5,  Bin Xu 6,  Liao-Yuan Li 7
Affiliations

Affiliations

  • 1 Department of Urology, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, 639 Zhizaoju Road, Shanghai, 200011, China.
  • 2 Department of Urology, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
  • 3 Department of Urology, Chinese PLA General Hospital, Beijing, China.
  • 4 Department of Health Management, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China.
  • 5 Department of Urology, Foshan First Municipal People's Hospital, Foshan, 528000, China.
  • 6 Department of Urology, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, 639 Zhizaoju Road, Shanghai, 200011, China. wjd_09122@163.com.
  • 7 Department of Urology, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, 639 Zhizaoju Road, Shanghai, 200011, China. liaoyuanli@sjtu.edu.cn.
  • # Contributed equally.
PMID: 40611320 DOI: 10.1186/s13046-025-03443-2
Abstract

For patients with prostate Cancer (PCa), pelvic lymph node (LN) metastasis remains a major poor prognostic factor associated with cancer-specific mortality. VEGF-C is a major lymphangiogenic ligand that plays a vital role in LN metastasis in PCa. However, in some PCa caseswith LN metastasis,VEGF-C is not upregulated, indicating that some VEGF-C-independent mechanisms are essential for lymphangiogenesis.Herein, we confirmed that extracellular vesicles (EVs) derived from PCa cells could promote LN metastasis in PCa independent of VEGF-C. We identified an EV circular RNA, circPDLIM5, that could promote lymphangiogenesis and lymphatic metastasis in both PCa cell lines and mouse models. Mechanistically, the packaging of circPDLIM5 into EVs was regulated by heterogeneous nuclear ribonucleoprotein A2B1. Subsequently, EVs were transmitted to human lymphatic endothelial cells, and EVs carrying circPDLIM5 could then directly interact with the transcription factor Yin Yang 1 to enhance the expression of Prospero homeobox 1, which is crucial for the formation, differentiation, and maturation of lymphatic vessels. Our findingshighlight the importance of a molecular mechanism mediated by EVs carrying circPDLIM5that is involved in lymphangiogenesis and LN metastasis in PCa; as a result, EVscarrying circPDLIM5 may be an attractive therapeutic target for LN-metastatic PCa.

Keywords

Circular RNA; Extracellular vesicles; Metastasis; Prostate cancer.

Figures
Products
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z