2. Academic Validation
  3. Preventive regulation of cellular heat stress injury by mung bean polyphenols revealed by multi-omics analysis

Preventive regulation of cellular heat stress injury by mung bean polyphenols revealed by multi-omics analysis

  • NPJ Sci Food. 2025 Jul 31;9(1):163. doi: 10.1038/s41538-025-00522-8.
Yuchao Feng 1 2,  Shu Zhang 2,  Decheng Suo 1,  Tianxin Fu 2,  Xiaonan Li 1,  Changyuan Wang 3,  Xia Fan 4
Affiliations

Affiliations

  • 1 State Key Laboratory for Quality and Safety of Agro-Products, Institute of Quality Standards and Testing Technology for Agro-Products, Chinese Academy of Agricultural Sciences, Beijing, China.
  • 2 College of Food, Heilongjiang Bayi Agricultural University, Daqing, China.
  • 3 College of Food, Heilongjiang Bayi Agricultural University, Daqing, China. byndwcy@163.com.
  • 4 State Key Laboratory for Quality and Safety of Agro-Products, Institute of Quality Standards and Testing Technology for Agro-Products, Chinese Academy of Agricultural Sciences, Beijing, China. fanxia@caas.cn.
PMID: 40744931 DOI: 10.1038/s41538-025-00522-8
Abstract

Based on the Caco-2 cell heat stress model, the study explored the heat stress preventive regulatory mechanisms of key polyphenol fractions in mung bean by metabolomics and transcriptomics association analysis. Results Mung bean polyphenol intervention before heat stress significantly reduced the elevated expression level of heat shock protein 70 (HSP70) caused by 39 °C temperature. At the metabolic level, mung bean Polyphenols could play a role in heat stress regulation by alleviating oxidative stress damage. At the gene level, mung bean Polyphenols showed regulation of cell proliferation, differentiation, and DNA damage, with DUSP6 and NEURL3 as key regulatory genes. The correlation analysis showed that nucleotide metabolism, and Oxidative Phosphorylation metabolism were the key pathways in the regulation of mung bean Polyphenols by heat stress. Then mung bean Polyphenols can exert heat stress preventive activity through the regulation of cellular oxidative damage and energy metabolism. This study provides a good idea for the research and development of dietary intervention products for heat stress.

Figures
Products
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z