Limiting endosomal damage sensing reduces inflammation triggered by lipid nanoparticle endosomal escape

Affiliations

• 1 Department of Bioengineering, School of Engineering and Applied Sciences, University of Pennsylvania, Philadelphia, PA, USA.
• 2 Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
• 3 Department of Chemistry, School of Arts and Sciences, University of Pennsylvania, Philadelphia, PA, USA.
• 4 Division of Rheumatology, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
• 5 Division of Pulmonary, Allergy, and Critical Care, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
• 6 Emergency Medical Department, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
• 7 Department of Pharmacology and Physiology, Drexel University College of Medicine, Philadelphia, PA, USA.
• 8 Division of Infectious Diseases, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
• 9 Department of Neurosciences, Case Western Reserve University, Cleveland, OH, USA.
• 10 Department of Bioengineering, George R. Brown School of Engineering, Rice University, Houston, TX, USA.
• 11 Department of Chemical Engineering, School of Engineering and Applied Sciences, University of Virginia, Charlottesville, VA, USA.
• 12 Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
• 13 Department of Chemical Engineering, Carnegie Mellon University, Pittsburgh, PA, USA.
• 14 Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, USA.
• 15 Department of Biomedical Engineering, Carnegie Mellon University, Pittsburgh, PA, USA.
• 16 Department of Bioengineering, School of Engineering and Applied Sciences, University of Pennsylvania, Philadelphia, PA, USA. Jacob.Brenner@pennmedicine.upenn.edu.
• 17 Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. Jacob.Brenner@pennmedicine.upenn.edu.
• 18 Division of Pulmonary, Allergy, and Critical Care, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. Jacob.Brenner@pennmedicine.upenn.edu.
• # Contributed equally.