2. Academic Validation
  3. Effects of Mytilus edulis derived plasmalogens against atherosclerosis via lipid metabolism and MAPK signaling pathway

Effects of Mytilus edulis derived plasmalogens against atherosclerosis via lipid metabolism and MAPK signaling pathway

  • NPJ Sci Food. 2025 Aug 18;9(1):178. doi: 10.1038/s41538-025-00546-0.
Junli Feng 1,  Jian Zhang 1,  Shitong Wang 1,  Zhenwei Li 2,  Hong Yuan 3,  Haiming Yao 3,  Jing Xue 1,  Jing Zheng 4,  Yeshun Wu 4,  Siwei Wang 4,  Xixi Zeng 4,  Yong Cui 5,  Oushan Tang 6,  Keyun Cheng 7,  Qing Shen 8 9
Affiliations

Affiliations

  • 1 Zhejiang Key Laboratory of Food Microbiology and Nutritional Health, Collaborative Innovation Center of Seafood Deep Processing, Institute of Seafood, Zhejiang Gongshang University, Hangzhou, China.
  • 2 Key Laboratory of Precision Medicine for Atherosclerotic Diseases of Zhejiang Province, Affiliated First Hospital of Ningbo University, Ningbo, China.
  • 3 Department of Cardiology, The First People's Hospital of Linping District, Hangzhou, China.
  • 4 Panvascular Diseases Research Center, The Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou People's Hospital, Quzhou, China.
  • 5 Heart Center, Department of Cardiovascular Surgery, Zhejiang Provincial People's Hospital (Affiliated People's Hospital, Hangzhou Medical College), Hangzhou, China. strait@126.com.
  • 6 Department of Cardiology, The Second Hospital Affiliated to Shaoxing University, Shaoxing, Zhejiang Province, China. tangoush@usx.edu.cn.
  • 7 Panvascular Diseases Research Center, The Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou People's Hospital, Quzhou, China. 1943882086@qq.com.
  • 8 Panvascular Diseases Research Center, The Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou People's Hospital, Quzhou, China. leonqshen@163.com.
  • 9 Laboratory of Food Nutrition and Clinical Research, Institute of Seafood, Zhejiang Gongshang University, Hangzhou, China. leonqshen@163.com.
PMID: 40826004 DOI: 10.1038/s41538-025-00546-0
Abstract

Mytilus edulis-derived plasmalogens (Pls) are rich in polyunsaturated fatty acids, which are reportedly effective in ameliorating Cardiovascular Disease. The purpose of this study was to clarify the underlying mechanisms of Pls against atherosclerosis (AS) in apoE-/- mice induced by a high-fat diet (HFD), through a comprehensive analysis of hepatic metabolomics and aortic transcriptomics data. The results demonstrated a significant reduction in pathological indicators associated with AS following Pls treatment. Furthermore, the abundance of hepatic lipid metabolites, which have either anti-inflammatory or pro-inflammatory effects, was significantly altered among experimental groups. Combined with transcriptomics data, it is suggested that these metabolic changes may inhibit MAPK signaling pathway, subsequently suppressing downstream vascular inflammatory responses and activity of NLRP3 inflammasome in Pls-treated mice. Collectively, this study supports the benefits of Pls as effective dietary bioactive Phospholipids in preventing HFD-induced AS and related metabolic disorders, possibly through modulation of the MAPK signaling pathway.

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