2. Academic Validation
  3. Plant anticancer agents. IX. Constituents of Hyptis tomentosa

Plant anticancer agents. IX. Constituents of Hyptis tomentosa

  • J Nat Prod. 1979 Sep-Oct;42(5):496-9. doi: 10.1021/np50005a010.
D G Kingston,  M M Rao,  W V Zucker
PMID: 521819 DOI: 10.1021/np50005a010
Abstract

The twigs, leaves, and flowers of Hyptis tomentosa were found to owe their major cytotoxic activity to the presence of desoxypodophyllotoxin (4), but the two weakly cytotoxic Flavones 5-hydroxy-4',6,7,8-tetramethoxy flavone (3) and 5-hydroxy-4',3,6,7,8-pentamethoxy flavone (2) also contributed to the total cytotoxicity of the crude extracts. The Flavones eupatorin (6) and 5-hydroxy-3',4',6,7-tetramethoxy flavone (5) were isolated as inactive constituents, together with the lignan sesamin (1).

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