2. Academic Validation
  3. 8-Aminoquinolines as anticoccidials--II

8-Aminoquinolines as anticoccidials--II

  • Bioorg Med Chem Lett. 1998 Jun 16;8(12):1487-92. doi: 10.1016/s0960-894x(98)00243-1.
R E Armer 1,  J S Barlow,  C J Dutton,  D H Greenway,  S D Greenwood,  N Lad,  A P Thompson,  K W Thong,  I Tommasini
Affiliations

Affiliation

  • 1 Animal Health Discovery, Pfizer Central Research, Sandwich, Kent, U.K.
PMID: 9873375 DOI: 10.1016/s0960-894x(98)00243-1
Abstract

During a chemistry program aimed at finding a novel analogue of pentaquine with improved in vivo activity, a number of hypotheses concerning the way this drug acts in the chicken were investigated. Consideration of the products of Monoamine Oxidase metabolism of pentaquine suggested that pentaquine aldehyde is the likely active metabolite. Although isolation of this unstable compound was not possible, oxime and cyclic acetal and ketal derivatives were obtained and shown to possess in vitro anticoccidial activity.

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