2. Academic Validation
  3. In vitro anti-human immunodeficiency virus (HIV) activity of the chromanone derivative, 12-oxocalanolide A, a novel NNRTI

In vitro anti-human immunodeficiency virus (HIV) activity of the chromanone derivative, 12-oxocalanolide A, a novel NNRTI

  • Bioorg Med Chem Lett. 1998 Aug 18;8(16):2179-84. doi: 10.1016/s0960-894x(98)00380-1.
Z Q Xu 1,  R W Buckheit Jr,  T L Stup,  M T Flavin,  A Khilevich,  J D Rizzo,  L Lin,  D E Zembower
Affiliations

Affiliation

  • 1 MediChem Research Inc., Lemont, IL 60439, USA.
PMID: 9873509 DOI: 10.1016/s0960-894x(98)00380-1
Abstract

The three chromanone derivatives, (+)-, (-)-, and (+/-)-12-oxocalanolide A (2), were evaluated for in vitro Antiviral activities against HIV and simian immunodeficiency virus (SIV). The compounds were determined to be inhibitors of HIV-1 Reverse Transcriptase (RT) and exhibited activity against a variety of viruses selected for resistance to other HIV-1 nonnucleoside RT inhibitors. They are the first reported calanolide analogues capable of inhibiting SIV.

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