2. Academic Validation
  3. Design and synthesis of analogs of vitamin E: antiproliferative activity against human breast adenocarcinoma cells

Design and synthesis of analogs of vitamin E: antiproliferative activity against human breast adenocarcinoma cells

  • Bioorg Med Chem Lett. 1998 Sep 22;8(18):2433-8. doi: 10.1016/s0960-894x(98)00438-7.
P Arya 1,  N Alibhai,  H Qin,  G W Burton,  G Batist,  S X You,  M A Alaoui-Jamali
Affiliations

Affiliation

  • 1 Steacie Institute for Molecular Sciences, National Research Council of Canada, Ottawa, Ontario.
PMID: 9873556 DOI: 10.1016/s0960-894x(98)00438-7
Abstract

Analogs of alpha-tocopherol (vitamin E; compounds 3-9) have been synthesized and tested for their antiproliferative activity using the human breast Cancer cell line, MCF7. Compounds 6-9 were synthesized from a common symthom, rac-Trolox (14) and are soluble/miscible at physiological pH. Compounds 4, 8, and 9 were found to have antiproliferative activity at micromolar concentrations.

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