2. Academic Validation
  3. Synthesis and comparative evaluation of two antiviral agents: beta-L-Fd4C and beta-D-Fd4C

Synthesis and comparative evaluation of two antiviral agents: beta-L-Fd4C and beta-D-Fd4C

  • Bioorg Med Chem Lett. 1998 Nov 17;8(22):3245-50. doi: 10.1016/s0960-894x(98)00599-x.
S H Chen 1,  S Lin,  I King,  T Spinka,  G E Dutschman,  E A Gullen,  Y C Cheng,  T W Doyle
Affiliations

Affiliation

  • 1 Vion Pharmaceuticals, Inc., Four Science Park, New Haven, CT 06511, USA.
PMID: 9873711 DOI: 10.1016/s0960-894x(98)00599-x
Abstract

The synthesis of beta-D-Fd4C was achieved in a stereoselective fashion from D-xylose. The Antiviral activity and cytotoxicity of beta-D-Fd4C was compared with that of beta-L-Fd4C and 3TC (Lamivudine). Of the three agents compared, beta-L-Fd4C was found to be the most potent Antiviral agent.

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