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  3. MEISi-2

MEISi-2 是一种选择性的 MEIS 抑制剂,MEIS 是造血干细胞 (HSC) 自我更新的关键调控因子。MEISi-2 被开发用于心脏损伤、造血问题、骨髓移植和癌症的研究。

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MEISi-2 Chemical Structure

MEISi-2 Chemical Structure

CAS No. : 2250156-71-7

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Top Publications Citing Use of Products
  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

MEISi-2 is a selective inhibitor of MEIS, a key regulator of hematopoietic stem cell (HSC) self-renewal. MEISi-2 is developed for the research of cardiac injuries, hematopoiesis issues, bone marrow transplantations, and cancer[1].

IC50 & Target

MEIS[1]

体外研究
(In Vitro)

MEISi-2 does not significantly inhibit the PBX-Luc-reporter[1].
MEISi-2 induces MEIS dependent hematopoietic stem cell maintenance and self-renewal[1].
MEISi-2 down-regulates MEIS target gene expression[1].
MEISi-2 induces murine (LSKCD34low cells) and human (CD34+, CD133+, and ALDHhi cells) HSC self-renewal ex vivo[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

MEISi-2 (10 µM; i.p.; at day 1, day 4 and day 7) functionally inhibits MEIS in vivo, thus they induces c-Kit+ cell, Sca1+ cell, CD150+ cell, LSK HSPCs, LSKCD34low HSC content and LSKCD150+CD48- HSC content[1].
MEISi-2 down-regulates Meis1 expression, Hif-2α, and key CDKI gene expression including p16, p19, p19ARF[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 4-6 week-old BALB/c mice[1]
Dosage: 10 µM/100 µL
Administration: Intraperitoneal injection, at day 1, day 4 and day 7
Result: Modulated HSC pool.
分子量

306.32

Formula

C18H14N2O3

CAS 号
性状

固体

颜色

Light yellow to yellow

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

H2O 中的溶解度 : < 0.1 mg/mL (insoluble)

DMSO 中的溶解度 : < 1 mg/mL (insoluble or slightly soluble)

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息:

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

由于实验过程有损耗,建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: 99.12%

参考文献

MEISi-2 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
MEISi-2
目录号:
HY-134259
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